Which body area is most commonly observed first to detect jaundice?

• A. Sclera
• B. Skin
• C. Nails
• D. Palms

Answer: (A)

The main idea here is how jaundice is seen first in clinical practice. When bilirubin levels rise, the pigment tends to show up in tissues where it’s easiest to notice a yellow tint. The whites of the eyes, the sclera, provide a nearly colorless backdrop, and the overlying conjunctiva is thin, so even small amounts of bilirubin color them yellow. That makes scleral icterus the most sensitive early sign.

Skin can also yellow, but pigment in darker skin tones can mask early jaundice, and nails or palms usually require higher bilirubin levels before their yellowing becomes apparent. So the sclera is the best first clue for most people, helping clinicians detect jaundice early across different skin tones.