To screen for disease-related weight change, which question would you ask?

• A. Have you noticed any intentional weight loss in the last 6 months?
• B. Have you noticed any unintentional weight loss in the last 6 months?
• C. Have you gained weight recently due to a new diet?
• D. Do you exercise regularly?

Answer: (B)

Focusing on unintentional weight change is key when screening for disease-related issues. If weight loss happens without the person trying to lose weight, it can be a sign of an underlying condition such as cancer, thyroid problems, infections, or gastrointestinal or metabolic disorders. Setting a six-month window helps capture meaningful changes that warrant further evaluation. In contrast, intentional weight loss reflects a deliberate plan (diet or increased activity) and is not typically a red flag for disease. Weight gain from a new diet or exercise program likewise isn’t specific to illness. So the most useful question is whether there has been unintentional weight loss in the past six months.