During fever resolution, what happens to pyrogens?

• A. Pyrogens Destroyed
• B. Pyrogens Produced
• C. Set Point Rises
• D. Temperature Remains Elevated

Answer: (A)

Fever ends when the pyrogens are cleared from the body, allowing the hypothalamic set point to return to normal. Pyrogens are what trigger the brain to raise the body's temperature, so once their signal fades, the brain lowers the set point. The body then cools itself through mechanisms like vasodilation and sweating, bringing the temperature back down.

That’s why this option is best: it reflects the idea that the fever subsides as the substances causing it are removed or neutralized. The other ideas—continued production of pyrogens, a rising set point during resolution, or the temperature staying high—would keep the fever going, which isn’t what happens during resolution.